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A new cytotoxic cholestane bisdesmoside from Ornithogalum saundersiae bulbs.

Abstract
Bioassay-guided fractionation of the MeOH extract of Ornithogalum saundersiae bulbs led to the isolation of a new cholestane bisdesmoside with potent cytotoxic activities toward leukemia HL-60 and MOLT-4 cells. The structure was deduced mainly from spectroscopic information.
AuthorsY Mimaki, M Kuroda, A Kameyama, Y Sashida, T Hirano, K Oka, K Koike, T Nikaido
JournalBioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 60 Issue 6 Pg. 1049-50 (Jun 1996) ISSN: 0916-8451 [Print] England
PMID8695908 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Cholestanes
  • Gallic Acid
  • 3,4,5-trimethoxybenzoic acid
Topics
  • Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
  • Carbohydrate Conformation
  • Carbohydrate Sequence
  • Cholestanes (chemistry, isolation & purification, pharmacology)
  • Drug Screening Assays, Antitumor
  • Gallic Acid (analogs & derivatives, chemistry)
  • HL-60 Cells
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Sequence Data
  • Plants (chemistry)
  • Tumor Cells, Cultured

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