Inhibitory effect of taraxastane-type triterpenes on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.

Abstract

Two taraxastane-type hydroxy triterpenes, taraxasterol and faradiol, isolated from the flowers of Compositae plants Cynara scolymus (artichoke) and Chrysanthemum morifilolium (chrysanthemum), respectively, showed strong inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. At 2.0 mumol/mouse, these compounds inhibited markedly the tumor-promoting effect of TPA (1 microgram/mouse) on skin tumor formation following initiation with 7,12-dimethylbenz[alpha]anthracene (50 micrograms/mouse).

• Authors: K Yasukawa, T Akihisa, H Oinuma, T Kaminaga, H Kanno, Y Kasahara, T Tamura, K Kumaki, S Yamanouchi, M Takido
• Journal: Oncology (Oncology) 1996 Jul-Aug Vol. 53 Issue 4 Pg. 341-4 ISSN: 0030-2414 [Print] Switzerland
• PMID: 8692541 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents
• Carcinogens
• Drugs, Chinese Herbal
• Sterols
• Triterpenes
• 9,10-Dimethyl-1,2-benzanthracene
• taraxasterol
• Tetradecanoylphorbol Acetate
• faradiol

Topics

• 9,10-Dimethyl-1,2-benzanthracene (toxicity)
• Animals
• Anticarcinogenic Agents (pharmacology)
• Carcinogens (toxicity)
• Drugs, Chinese Herbal
• Edema (chemically induced, prevention & control)
• Female
• Inflammation
• Mice
• Mice, Inbred ICR
• Skin Neoplasms (chemically induced, prevention & control)
• Sterols (pharmacology)
• Tetradecanoylphorbol Acetate (toxicity)
• Triterpenes (pharmacology)
• Vegetables