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The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism.

AbstractOBJECTIVE:
To investigate the effects of low dose flutamide (250 mg/d) on hirsutism score and hormone levels in women with hirsutism.
DESIGN:
Nonrandomized, prospective clinical trial.
PATIENTS:
Forty-one patients with moderate-severe hirsutism were included in the study.
INTERVENTION:
Hirsute patients received 250 mg/d flutamide for a period of 6 months.
MAIN OUTCOME MEASURES:
Hirsutism score, FSH, LH, E2, total T, free T, androstenedione, DHEAS, PRL, 17-hydroxyprogesterone, and sex hormone-binding globulin levels were detected in all the patients before treatment and every 3 months during treatment.
RESULTS:
Treatment with the antiandrogen flutamide resulted in a particularly rapid and marked decrease in the hirsutism score, which decreased from 17.48 +/- 5.35 to 5.07 +/- 2.89 after 6 months. No significant changes in the levels of hormone and no serious side effects were observed in the study.
CONCLUSION:
The low-dose flutamide, 250 mg/d, is a cost-effective drug in the treatment of hirsutism. Low-dose flutamide may be used in place of high-dose flutamide, 500 to 750 mg/d.
AuthorsI I Müderris, F Bayram, Y Sahin, F Keleştimur, A Tutuş, D Ayata
JournalFertility and sterility (Fertil Steril) Vol. 66 Issue 2 Pg. 220-2 (Aug 1996) ISSN: 0015-0282 [Print] United States
PMID8690105 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Androgen Antagonists
  • Estrogens
  • Testosterone
  • Androstenedione
  • Progesterone
  • Flutamide
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
Topics
  • Adolescent
  • Adult
  • Androgen Antagonists (therapeutic use)
  • Androstenedione (blood)
  • Dose-Response Relationship, Drug
  • Estrogens (blood)
  • Female
  • Flutamide (therapeutic use)
  • Follicle Stimulating Hormone (blood)
  • Hirsutism (blood, drug therapy)
  • Humans
  • Luteinizing Hormone (blood)
  • Progesterone (blood)
  • Prospective Studies
  • Testosterone (blood)

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