Abstract | OBJECTIVE: DESIGN: Prospective randomized single-blinded study. SETTING: PATIENTS: Forty-two premenopausal patients with hirsutism were selected. INTERVENTIONS: Subjects were randomized to receive either 100 mg spironolactone and an oral contraceptive (OC) containing 150 microg desogestrel and 30 microg ethinyl E2 or 50 mg CPA daily on days 1 to 10 of the menstrual cycle, which was administered with 35 microg ethinyl E2 daily on days 1 to 21. MAIN OUTCOME MEASURES:
Hirsutism scores were measured according to Ferriman-Gallwey scoring system and side effects were monitored for 9 months of treatment. Blood samples were taken at each visit for assessment of endocrine, biochemical, and hematologic parameters. RESULTS:
Hirsutism scores were decreaded significantly in both groups at the end of 9 months. The percent of change in hirsutism scores in CPA and spironolactone group were as follows: 19.23% +/- 14.77% and 24.48% +/- 14.27% at 3 months; 39.01% +/- 19.77% and 37.46% +/- 16.90% at 6 months; and 51.89% +/- 20.87% and 46.39% +/- 16.10% at 9 months, respectively. There was a trend toward a better response with CPA treatment, which did not achieve significance. None of the patients stopped treatment because of side effects. CONCLUSION:
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Authors | M Erenus, D Yücelten, O Gürbüz, F Durmuşoğlu, S Pekin |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 66
Issue 2
Pg. 216-9
(Aug 1996)
ISSN: 0015-0282 [Print] United States |
PMID | 8690104
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Contraceptives, Oral, Synthetic
- Hydroxyprogesterones
- Mineralocorticoid Receptor Antagonists
- Progesterone Congeners
- Spironolactone
- Testosterone
- Ethinyl Estradiol
- Cyproterone Acetate
- 17-alpha-Hydroxyprogesterone
- Desogestrel
- Luteinizing Hormone
- Follicle Stimulating Hormone
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Topics |
- 17-alpha-Hydroxyprogesterone
- Adolescent
- Adult
- Contraceptives, Oral, Synthetic
(therapeutic use)
- Cyproterone Acetate
(therapeutic use)
- Desogestrel
(therapeutic use)
- Drug Therapy, Combination
- Ethinyl Estradiol
(therapeutic use)
- Female
- Follicle Stimulating Hormone
(blood)
- Hirsutism
(blood, drug therapy)
- Humans
- Hydroxyprogesterones
(blood)
- Luteinizing Hormone
(blood)
- Mineralocorticoid Receptor Antagonists
(therapeutic use)
- Progesterone Congeners
(therapeutic use)
- Prospective Studies
- Single-Blind Method
- Spironolactone
(therapeutic use)
- Testosterone
(blood)
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