Abstract | BACKGROUND: METHODS:
Hypoxia was induced by ventilation with 8% O(2) in 30 piglets with fixed ventilation. When the pH fell to < 7.2, hypoxia was reversed by placing the animals in 21% O2 (experiment 1) or 100% O(2) (experiment 2) and either saline, Carbicarb or NaHCO3 were given. Data were collected for 120 minutes after therapy. RESULTS: In both experiment 1 (severe acidosis, pH < or = 7.1) and 2 (moderate acidosis, pH < or = 7.2) use of Carbicarb and NaHCO3 increased the arterial carbon dioxide tension (pCO2) significantly (p < 0.05). With moderate acidosis: 1) use of alkalinizing agents compared to saline resulted in an initial improvement in arterial pH at 1 minute, but thereafter, the differences were not statistically significant; and 2) there were no differences in hemodynamic variables and plasma lactic acid concentration between the three groups. CONCLUSIONS:
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Authors | M A Basir, J Bhatia, D S Brudno, L I Kleinman |
Journal | Journal of investigative medicine : the official publication of the American Federation for Clinical Research
(J Investig Med)
Vol. 44
Issue 2
Pg. 70-4
(Feb 1996)
ISSN: 1081-5589 [Print] England |
PMID | 8689404
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carbonates
- Drug Combinations
- sodium bicarbonate, sodium carbonate drug combination
- Sodium Bicarbonate
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Topics |
- Acid-Base Equilibrium
(drug effects, physiology)
- Acidosis, Lactic
(physiopathology)
- Animals
- Animals, Newborn
- Carbonates
(pharmacology)
- Drug Combinations
- Female
- Fetal Hypoxia
(physiopathology)
- Male
- Sodium Bicarbonate
(pharmacology)
- Swine
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