The course and prognosis of
septic shock developing during
agranulocytosis were retrospectively studied in 59 hematological patients (52 ones with hemoblastosis and 7 with
aplastic anemia). Out of 59 patients with
septic shock hospitalized at department for anesthesiology and reanimation, in 5
shock was arrested and they were transferred to other departments of the hospital. All patients with failure of more than three organ systems, with SAPS score of 21 at admission, and a history of
splenectomy died in the anesthesiology and reanimation department. The diagnosis of the underlying
disease, resistance to
chemotherapy administered, disease stage, persistent
agranulocytosis, and artificial ventilation of the lungs which had to be resorted to did not influence the prognosis of
septic shock. Even after effective antishock
therapy all patients with
aplastic anemia died, as did the patients with resistance to
chemotherapy administered for the underlying disease and those without signs of granulocytopoiesis recovery. Hence, the prognosis is unfavorable for patients with
septic shock in a state of
agranulocytosis, if their SAPS score on admission is higher than 21, if they develop polyorgan failure with involvement of more than three organ systems, have a history of
splenectomy, their hemoblastosis is resistant to
chemotherapy, and there are no prospects for granulocytopoiesis recovery.