[Randomized trial and meta-analysis of somatostatin versus placebo in bleeding esophageal varices].
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| Abstract |
We studied whether somatostatin or its derivative, octreotide, is more effective than placebo in the treatment of bleeding oesophageal varices in a randomised, double-blind trial and a meta-analysis with blinded data analysis and manuscript writing. Patients suspected of bleeding from oesophageal varices and of having cirrhosis of the liver were eligible. Eighty-six patients were randomised; 16 died in each group within six weeks (95% confidence interval (CI) for difference in mortality -19% to 22%). There were no differences between somatostatin and placebo in median number of blood transfusions (8 vs 5, p = 0.07, CI 0 to 4 transfusions) or in numbers of patients who needed balloon tamponade (16 vs 13, p = 0.54, CI -11% to 28%). In a meta-analysis of three trials, involving 290 patients, somatostatin had no effect on survival compared with placebo (p = 0.59, odds ratio 1.16, CI 0.67 to 2.01). For blood transfusions and use of balloon tamponade there was heterogeneity between the trials with no convincing evidence in favour of somatostatin.
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| Authors | P C Gøtzsche, I E Gjørup, H Bonnén, N E Brahe, P U Becker, F Burcharth |
| Journal | Ugeskrift for laeger (Ugeskr Laeger) Vol. 158 Issue 17 Pg. 2393-6 (Apr 22 1996) ISSN: 0041-5782 [Print] Denmark |
| Vernacular Title | Randomiseret undersøgelse og metaanalyse af somatostatin over for placebo ved blødende esophagusvaricer. |
| PMID | 8685994 (Publication Type: Clinical Trial, Clinical Trial, Phase II, English Abstract, Journal Article, Meta-Analysis, Randomized Controlled Trial) |
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