Abstract | PURPOSE: METHODS: Forty patients with chronic intermediate, posterior, or panuveitis associated cystoid macular edema were randomized into a masked, cross-over trial comparing acetazolamide versus placebo. Patients received an initial 4-week course of either acetazolamide or placebo (course A) followed by a 4-week washout period. They then received a 4-week course of the opposite study medication (course B). Primary endpoints included area of cystoid macular edema measured on late-phase views of fluorescein angiography and visual acuity. RESULTS: Thirty-seven patients completed the trial and were available for analysis; 17 (46%) were randomized to receive acetazolamide and 20 (54%) to receive placebo during course A. Acetazolamide resulted in a 0.5-disc area (25%) decrease in cystoid macular edema over that of placebo (P = 0.01; estimated treatment effect = -0.5 disc areas; 95% confidence interval, -0.9 to -0.1). However, there was no statistically significant effect of acetazolamide on visual acuity (P = 0.61; estimated treatment effect = 0.6 letters; 95% confidence interval, -2 to 3). CONCLUSIONS:
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Authors | S M Whitcup, K G Csaky, M J Podgor, E Y Chew, C H Perry, R B Nussenblatt |
Journal | Ophthalmology
(Ophthalmology)
Vol. 103
Issue 7
Pg. 1054-62; discussion 1062-3
(Jul 1996)
ISSN: 0161-6420 [Print] United States |
PMID | 8684794
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Carbonic Anhydrase Inhibitors
- Acetazolamide
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Topics |
- Acetazolamide
(adverse effects, therapeutic use)
- Adolescent
- Adult
- Aged
- Carbonic Anhydrase Inhibitors
(adverse effects, therapeutic use)
- Chronic Disease
- Cross-Over Studies
- Double-Blind Method
- Female
- Fluorescein Angiography
- Fundus Oculi
- Humans
- Macular Edema
(drug therapy, etiology, pathology)
- Male
- Middle Aged
- Uveitis
(complications)
- Visual Acuity
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