[Drug-induced asterixis amplified by relative hypoglycemia].

Abstract

A 58-year-old man with chronic paranoid-hallucinatoric psychosis had transient episodes with marked paranoid delusions, auditory hallucinations without confusion, shakiness of both upper extremities, tachycardia and sweating. EMG performed with surface electrodes revealed many silent periods in postural active muscles with maximum duration of 120 ms; blood glucose was 65-75 mg/dl. At other times, blood glucose was 135-140 mg/dl, EMG revealed few silent periods in postural active muscles with maximal duration of 50 ms and the patient noted some vibration in his outstretched hands only. Drug-induced asterixis (clozapine, benperidol) amplified by relative hypoglycemia was therefore assumed, and symptoms disappeared after oral antidiabetics were reduced.

• Authors: M Poersch, A Hufnagel, C Smolenski
• Journal: Der Nervenarzt (Nervenarzt) Vol. 67 Issue 4 Pg. 323-6 (Apr 1996) ISSN: 0028-2804 [Print] Germany
• Vernacular Title: Medikamentös induzierte Asterixis verstärkt durch relative Hypoglykämie.
• PMID: 8684512 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antipsychotic Agents
• Hypoglycemic Agents
• Clozapine
• Glyburide

Topics

• Antipsychotic Agents (administration & dosage, adverse effects)
• Clozapine (administration & dosage, adverse effects)
• Diabetes Mellitus, Type 2 (drug therapy, physiopathology)
• Dose-Response Relationship, Drug
• Drug Therapy, Combination
• Electromyography (drug effects)
• Fasciculation (chemically induced, physiopathology)
• Glyburide (administration & dosage, adverse effects)
• Hallucinations (drug therapy, physiopathology)
• Humans
• Hypoglycemia (complications, physiopathology)
• Hypoglycemic Agents (administration & dosage, adverse effects)
• Male
• Middle Aged
• Motor Neurons (drug effects, physiology)
• Muscle, Skeletal (innervation)
• Myoclonus (chemically induced, physiopathology)
• Neurologic Examination (drug effects)
• Paranoid Disorders (drug therapy, physiopathology)
• Tremor (chemically induced, physiopathology)