Abstract |
2,4-dichloro-6-nitrophenol ammonium (DCNPA) is used as a herbicide. However, information on the potential health hazards of DCNPA is limited. In a previous study, we found that DCNPA is genotoxic to Bacillus subtilis and yeast. Further studies were performed to determine whether DCNPA and its major metabolite, 2,4-dichloro-6-aminophenol ( DCAP), can induce reverse mutations in Salmonella, gene mutations at the HPRT locus, sister chromatid exchanges (SCEs) and micronuclei (MN) in V79 cells. Results show that DCNPA does not produce a positive response for any endpoint at concentrations tested. However, treatment of V79 cultures with DCAP caused a significant increase in SCEs and MN in a concentration-dependent manner. These results indicate that DCAP damages DNA and causes chromosomal aberrations in V79 cells. Therefore, DCNPA could pose potential health hazards to populations exposed to this herbicide.
|
Authors | Z C Heng, T Ong, J Nath |
Journal | Mutation research
(Mutat Res)
Vol. 368
Issue 2
Pg. 149-55
(Jun 12 1996)
ISSN: 0027-5107 [Print] Netherlands |
PMID | 8684405
(Publication Type: Journal Article)
|
Chemical References |
- Aminophenols
- Benzamides
- Herbicides
- Mutagens
- 2,4-dichloro-6-nitrophenolamide
- 3,5-dichloro-1,4-aminophenol
|
Topics |
- Aminophenols
(toxicity)
- Animals
- Benzamides
(toxicity)
- Cell Survival
(drug effects)
- Cells, Cultured
- Cricetinae
- Herbicides
(toxicity)
- Micronucleus Tests
- Mutagenicity Tests
- Mutagens
(toxicity)
- Salmonella typhimurium
(drug effects)
- Sister Chromatid Exchange
(drug effects)
|