Abstract |
To assess the efficacy of GnRH-agonist therapy in the treatment of endometriomas with or without surgical intervention, 26 women with laparoscopically proven endometriomas larger than 3 cm were recruited to the study. Fourteen women with 19 endometriomas (5 bilateral), had drainage of endometrioma at initial laparoscopy. After the procedure, ovarian suppression was done with GnRH-a therapy for 6 months. The second group which consisted of 12 women, had 17 endometriomas. No surgical procedure was performed. They received only GnRH-a therapy for 6 months. On repeat laparoscopy, in the first group, the rates of decrease in ovarian AFS scores of endometriomas and complete resolution were found as 100% and 37% respectively. In the second group the response was only 18% (p < 0.0001). It was concluded that drainage of the cyst (surgical therapy) combined with postoperative GnRH-a suppression is a better treatment modality than the use of GnRH-a (medical therapy) alone for endometriomas.
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Authors | S Batioglu, H Celikkanat, M Ugur, L Mollamahmutoglu, H Yesilyurt, M Kundakci |
Journal | JPMA. The Journal of the Pakistan Medical Association
(J Pak Med Assoc)
Vol. 46
Issue 2
Pg. 30-2
(Feb 1996)
ISSN: 0030-9982 [Print] Pakistan |
PMID | 8683844
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Adult
- Combined Modality Therapy
- Drainage
- Endometriosis
(therapy)
- Female
- Humans
- Laparoscopy
- Ovarian Diseases
(therapy)
- Triptorelin Pamoate
(administration & dosage, adverse effects)
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