Abstract | BACKGROUND/AIMS: There are genetic, endoengenous, and exogenous factors responsible for colorectal cancer. Calcium may play a chemopreventive role in high risk groups. Binding fatty and biliary acids and their reduced absorbtion, with a consequent decrease of proliferative stimulation and reduction of secondary carcinogenic compounds, may explain this role. MATERIAL AND METHODS: RESULTS: The cumulative survival rate of patients after surgery due to colorectal carcinoma is significantly higher in a calcium chemopreventive group. Adenomatous polyps recurrences after polypectomy are lower (12.9%) in the chemoprevention group than in the group without prevention (55%) with a mean time of follow-up 3.1 yrs. CONCLUSIONS:
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Authors | I Duris, D Hruby, B Pekarkova, M Huorka, E Cernakova, T Bezayova, P Ondrejka |
Journal | Hepato-gastroenterology
(Hepatogastroenterology)
1996 Jan-Feb
Vol. 43
Issue 7
Pg. 152-4
ISSN: 0172-6390 [Print] Greece |
PMID | 8682453
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Adenomatous Polyposis Coli
(mortality, prevention & control, surgery)
- Adult
- Aged
- Calcium
(therapeutic use)
- Colorectal Neoplasms
(mortality, prevention & control, surgery)
- Female
- Humans
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(prevention & control)
- Survival Rate
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