Abstract | PURPOSE: METHODS: Electroconvulsions were produced by means of an alternating current (ear- clip electrodes, 0.2-s stimulus duration, tonic hindlimb extension taken as the end point) delivered by a Hugo-Sachs stimulator (Type 221, reiburg, FRG). Adverse effects were evaluated in the chimney test (motor performance) and passive-avoidance ask (long-term memory). Plasma levels of antiepileptic rugs were measured by immunofluorescence. RESULTS: CONCLUSIONS: It may be concluded that NMDA-receptor blockade leads to the enhanced anticonvulsive action of conventional antiepileptics against maximal electroshock-induced seizures. A pharmacokinetic interaction does not seem probable.
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Authors | K K Borowicz, M Gasior, Z Kleinrok, S J Czuczwar |
Journal | Epilepsia
(Epilepsia)
Vol. 37
Issue 7
Pg. 618-24
(Jul 1996)
ISSN: 0013-9580 [Print] United States |
PMID | 8681893
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticonvulsants
- Excitatory Amino Acid Antagonists
- Isoquinolines
- Pipecolic Acids
- Receptors, N-Methyl-D-Aspartate
- Tetrazoles
- LY 233053
- LY 235959
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Topics |
- Animals
- Anticonvulsants
(blood, pharmacology, therapeutic use)
- Avoidance Learning
(drug effects)
- Disease Models, Animal
- Drug Synergism
- Electroshock
- Epilepsy
(drug therapy)
- Excitatory Amino Acid Antagonists
(pharmacology, therapeutic use)
- Female
- Humans
- Isoquinolines
(pharmacology, therapeutic use)
- Kindling, Neurologic
(drug effects)
- Memory
(drug effects)
- Mice
- Motor Activity
(drug effects)
- Pipecolic Acids
(pharmacology, therapeutic use)
- Receptors, N-Methyl-D-Aspartate
(antagonists & inhibitors)
- Seizures
(prevention & control)
- Tetrazoles
(pharmacology, therapeutic use)
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