[Immune response to a single dose of a novel kind of hepatitis A vaccine following splenectomy].

Abstract

BASIC PROBLEM AND OBJECTIVE:

The immune response to parenteral antigens is reduced in persons without spleen. The seroconversion rate was measured after application of a new type of vaccine against hepatitis A (immunopotentiating reconstituted influenza virus virosome [IRIV]) in patients who had undergone a splenectomy after trauma.

PATIENTS AND METHODS:

26 patients (23 men and 3 women, mean age 34.9 +/- 9.7 [25-65] years) with anti-hepatitis A virus (HAV) antibody titres < 20 mIU/ml (maximally 17 mIU/ml) were given a single dose of 0.5 ml of the IRIV hepatitis A vaccine 1 to 14 (mean 9.4) years after splenectomy. Immediately after the immunisation and 14 and 28 days afterwards anti-HAV titres were determined. A titre rise to < 20 mIU/ml was counted as seroconversion. At the first and last titre measurement immunoglobulins, neopterin and beta-microglobulin levels were also measured as additional markers.

RESULTS:

The seroconversion rate was 69.2% (18/26) after 14 days (geometric titre mean: 39 mIU/ml) and rose to 88.5% (23/26) after 28 days (geometric titre mean 74 mIU/ml). Seroconversion occurred in the three nonresponders after a second dose of the vaccine. All measurements of the immunological markers were within normal limits.

CONCLUSION:

A single dose of a new type of vaccine against hepatitis A confers adequate protection even in those persons who had a splenectomy.

• Authors: H P Simmen, L Robustelli, B Althaus, R Glück, O Trentz, M Vogt
• Journal: Deutsche medizinische Wochenschrift (1946) (Dtsch Med Wochenschr) Vol. 121 Issue 10 Pg. 295-8 (Mar 08 1996) ISSN: 0012-0472 [Print] Germany
• Vernacular Title: Immunantwort einer Einzeldosis eines neuartigen Hepatitis-A-Impfstoffes nach Splenektomie.
• PMID: 8681712 (Publication Type: English Abstract, Journal Article)

Chemical References

• Hepatitis A Antibodies
• Hepatitis A Vaccines
• Hepatitis Antibodies
• Vaccines, Inactivated
• Viral Hepatitis Vaccines

Topics

• Adult
• Aged
• Female
• Hepatitis A Antibodies
• Hepatitis A Vaccines
• Hepatitis Antibodies (isolation & purification)
• Hepatovirus (immunology)
• Humans
• Male
• Middle Aged
• Splenectomy
• Vaccines, Inactivated (immunology)
• Viral Hepatitis Vaccines (immunology)