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T-cell lymphoma presenting with pericardial and pleural effusion as the initial and primary lesion: cytogenetic and molecular evidence.

Abstract
A 90-year-old woman was admitted with progressive dyspnea. Chest roentgenogram and computed tomography revealed a massive pericardial effusion and bilateral pleural effusion, but no lymphomatous lesion was seen. A diagnosis of malignant lymphoma was made by cytological and immunological studies of the cells obtained from the pericardial effusion. Chromosome analysis showed a clonal abnormality and T-lineage clonality was determined by the rearrangement of the T-cell receptor gamma gene. The patient achieved remission with chemotherapy, but she later relapsed, with right pleural effusion, and died. She exhibited no lymphomatous features throughout the clinical course, indicating the possibility of malignant lymphoma originating from the pericardium and/or pleura.
AuthorsH Yasuda, M Nakao, H Kanemasa, T Ueha, T Mori, H Fujino, T Oishi, M Ohta, Y Inada, H Tanigawa, S Horiike, S Yokota, S Misawa, K Kashima
JournalInternal medicine (Tokyo, Japan) (Intern Med) Vol. 35 Issue 2 Pg. 150-4 (Feb 1996) ISSN: 0918-2918 [Print] Japan
PMID8680105 (Publication Type: Case Reports, Journal Article)
Chemical References
  • DNA, Neoplasm
  • Receptors, Antigen, T-Cell, gamma-delta
Topics
  • Aged
  • Aged, 80 and over
  • Blotting, Southern
  • Chromosome Aberrations (diagnosis)
  • Chromosome Disorders
  • DNA, Neoplasm (analysis)
  • Echocardiography
  • Female
  • Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor (genetics)
  • Humans
  • Lung (diagnostic imaging)
  • Lymphoma, T-Cell (diagnosis, genetics)
  • Pericardial Effusion (diagnosis, genetics)
  • Pleural Effusion (diagnosis, genetics)
  • Receptors, Antigen, T-Cell, gamma-delta (genetics)
  • Tomography, X-Ray Computed

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