Adrenal tumor producing 11-deoxycorticosterone, 18-hydroxy-11-deoxycorticosterone and aldosterone.

Abstract

A case of adrenal tumor producing 11-deoxycorticosterone, 18-hydroxy-11-deoxycorticosterone and aldosterone is reported. A 55-year-old woman had hypertension, hypokalemia, low plasma renin activity and an adrenal tumor. The plasma level of aldosterone was normal, and the levels of 11-deoxycorticosterone and 18-hydroxy-11-deoxycorticosterone were extremely high. After the tumor removal, the plasma level of aldosterone decreased and plasma levels of 11-deoxycorticosterone and 18-hydroxy-11-deoxycorticosterone were normalized. The tumor was benign adenoma and the production of steroid hormones was under control of adrenocorticotropic hormone. The enzyme activity of 21-hydroxylation in the tumor was elevated and that of 11 beta-hydroxylation was decreased compared with the adjacent tissue.

• Authors: Y Toyoda, M Mizukoshi, M Umemoto, M Kuchii, K Ueyama, S Tomimoto, A Baba, H Shima, I Nishio, Y Masuyama
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 35 Issue 2 Pg. 123-8 (Feb 1996) ISSN: 0918-2918 [Print] Japan
• PMID: 8680100 (Publication Type: Case Reports, Journal Article)

Chemical References

• 18-Hydroxydesoxycorticosterone
• Desoxycorticosterone
• Aldosterone
• Renin
• Hydrocortisone

Topics

• 18-Hydroxydesoxycorticosterone (blood)
• Adenoma (diagnosis, metabolism, surgery)
• Adrenal Gland Neoplasms (diagnosis, metabolism, surgery)
• Aldosterone (metabolism)
• Desoxycorticosterone (metabolism)
• Female
• Humans
• Hydrocortisone (blood)
• Hypertension (complications)
• Hypokalemia (complications)
• Middle Aged
• Renin (blood)
• Tomography, X-Ray Computed