Abstract | UNLABELLED: METHODS: After approval of the local ethics committee and informed consent 40 patients (age > 18 year, ASA I-III) were studied. Following randomization, the patients each received a PCA device containing either clonidine (bolus 30 micrograms), or piritramide (bolus 1.5 mg) for treatment of postoperative pain (lockout interval 5 min in both groups). During the postoperative period, pain was determined using a visual analogue scale, while analgesic consumption, sedation, haemodynamic parameters, respiration rate, and the occurrence of undesired side effects were documented additionally. RESULTS: The groups had comparable distributions of biometric data, duration of anaesthesia, and ASA classification. Pain level decreased significantly (P < 0.0001) in both groups during the first 2 h of PCA. Mean arterial pressure and heart rate were lower (P < 0.05) in the clonidine group 4 and 6 h after PCA onset, while the degree of sedation after 2 (P < 0.01) and 6 (P < 0.05) h was higher than in the piritramide group. Nausea and vomiting were more frequent (P < 0.05) in the piritramide group. Both groups showed a wide interpatient variation in analgesic requirement. The equipotency ratio clonidine/ piritramid was 1:63.7. CONCLUSION:
|
Authors | R Sümpelmann, H Büsing, D Schröder, M Rekersbrink, S Krohn, J M Strauss |
Journal | Der Anaesthesist
(Anaesthesist)
Vol. 45
Issue 1
Pg. 88-94
(Jan 1996)
ISSN: 0003-2417 [Print] Germany |
Vernacular Title | Patienten-kontrollierte Analgesie mit Clonidin und Piritramid. |
PMID | 8678284
(Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Analgesics, Opioid
- Sympatholytics
- Pirinitramide
- Clonidine
|
Topics |
- Adolescent
- Adult
- Aged
- Analgesia, Patient-Controlled
- Analgesics, Opioid
(administration & dosage, adverse effects)
- Clonidine
(administration & dosage, adverse effects)
- Dose-Response Relationship, Drug
- Female
- Humans
- Male
- Middle Aged
- Pain Measurement
- Pain, Postoperative
(drug therapy)
- Pirinitramide
(administration & dosage, adverse effects)
- Prospective Studies
- Sympatholytics
(administration & dosage, adverse effects)
|