Abstract | OBJECTIVE: Our purpose was to evaluate the efficacy and toxicity of single-agent chemotherapy and to identify risk factors associated with chemotherapy resistance in the treatment of low-risk metastatic gestational trophoblastic tumors. STUDY DESIGN: RESULTS: All 92 patients with low-risk metastatic gestational trophoblastic tumors were cured. Primary remission was achieved with initial single-agent therapy in 62 patients (67.4%). A second sequential single agent was used because of drug resistance in 20 patients (21.7%) or drug toxicity in 10 patients (10.9%). Only one patient (1%) needed multiagent chemotherapy to be cured. Adjuvant hysterectomy was performed in 22 patients (23.9%). Surgery was not required to remove resistant tumor foci. Chemotherapy toxicity, most commonly stomatitis, occurred in 36 patients (39.1%), but none of these effects was life threatening. Large vaginal metastasis was the only identifiable factor significantly associated with failure of initial single-agent chemotherapy (p = 0.03). CONCLUSION:
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Authors | J P Roberts, J R Lurain |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 174
Issue 6
Pg. 1917-23; discussion 1923-4
(Jun 1996)
ISSN: 0002-9378 [Print] United States |
PMID | 8678159
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Chorionic Gonadotropin
- Dactinomycin
- Methotrexate
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Topics |
- Adolescent
- Adult
- Antineoplastic Agents
(administration & dosage, adverse effects, therapeutic use)
- Chorionic Gonadotropin
(blood)
- Combined Modality Therapy
- Dactinomycin
(administration & dosage, adverse effects, therapeutic use)
- Drug Resistance, Neoplasm
- Female
- Humans
- Hysterectomy
- Methotrexate
(administration & dosage, adverse effects, therapeutic use)
- Middle Aged
- Neoplasm Metastasis
- Pregnancy
- Risk Factors
- Trophoblastic Neoplasms
(drug therapy, surgery)
- Uterine Neoplasms
(drug therapy, surgery)
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