Effects of low-protein diet supplemented with ketoacids on plasma lipids in adult chronic renal failure.

Abstract

We designed a short-term randomized controlled study in 12 adult patients with chronic renal failure to assess the metabolic effects of a low-protein diet (LPD) supplemented or not with ketoacids (Cetolog, Clintec Corp., France). Dietary survey included a monthly 3-day food record and a 24-hour urinary urea measurement. After a baseline period (1.11 g protein, 31.7 kcal/kg BW/day), patients reduced their protein intake (PI) to 0.71 g/kg BW/day. Energy intake (EI) was kept constant (31.4 kcal/kg BW/day) during the 3-month period. Baseline plasma lipids did not show overt hyperlipemia. After reducing PI, a significant increase in apolipoprotein AI and the Apo-AI/Apo-B ratio was observed. Plasma Lp(a) levels were elevated at baseline and did not change during the 3-month LPD period. There was no difference between groups receiving ketoacids or not. Thus, in adult chronic renal failure, under a sufficient EI, reducing PI by 40% had a beneficial effect on plasma lipid profile. This improvement in lipid profile might reduce the high cardiovascular risk in these patients.

• Authors: S Bernard, D Fouque, M Laville, P Zech
• Journal: Mineral and electrolyte metabolism (Miner Electrolyte Metab) Vol. 22 Issue 1-3 Pg. 143-6 ( 1996) ISSN: 0378-0392 [Print] Switzerland
• PMID: 8676807 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Amino Acids
• Apolipoprotein A-I
• Apolipoproteins B
• Keto Acids
• Lipids
• Lipoprotein(a)
• Triglycerides
• Cholesterol

Topics

• Adult
• Amino Acids
• Apolipoprotein A-I (blood)
• Apolipoproteins B (blood)
• Cholesterol (blood)
• Diet, Protein-Restricted
• Energy Intake
• Energy Metabolism
• Female
• Food, Fortified
• Humans
• Keto Acids
• Kidney Failure, Chronic (blood, diet therapy)
• Lipids (blood)
• Lipoprotein(a) (blood)
• Male
• Triglycerides (blood)