| Abstract | Using a lactoferrin latex agglutination assay, we have compared the inflammatory responses to a cholera vaccine candidate, CVD 110, in which all known toxin genes have been deleted or mutated yet still produced significant diarrhea, with a less reactive vaccine strain and wild-type El Tor and 0139 Vibrio cholerae strains. Data suggest that diarrhea due to attenuated and wild-type El Tor V. cholerae, and to a lesser extent 0139 V. cholerae, involves an inflammatory response. Further study is required to further elucidate the mechanism of the process(es) involved. |
| Authors | T M Silva, M A Schleupner, C O Tacket, T S Steiner, J B Kaper, R Edelman, R Guerrant
(Affiliation: Division of Geographic and International Medicine, University of Virginia School of Medicine, Charlottesville, USA.)
|
| Journal | Infection and immunity
(Infect Immun)
Vol. 64
Issue 6
Pg. 2362-4
(Jun 1996)
ISSN: 0019-9567 UNITED STATES |
| PMID | 8675353
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Cholera Vaccines
- Lactoferrin
- Vaccines, Attenuated
|
| Topics |
- Cholera Vaccines
(adverse effects)
- Diarrhea
(etiology)
- Humans
- Inflammation
(etiology)
- Lactoferrin
(analysis)
- Neutrophils
(physiology)
- Vaccines, Attenuated
(adverse effects)
- Vibrio cholerae
(pathogenicity)
|
