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Altered cerebrovascular response to a potassium channel opener in hypertensive rats.

Abstract
We examined whether the effect of Y-26763, an ATP-sensitive potassium channel opener, on cerebral blood flow is altered in stroke-prone spontaneously hypertensive rats (SHRSP) and, if altered, whether long-term antihypertensive treatment with cilazapril, an angiotensin-converting enzyme inhibitor, is capable of preventing the change. Cerebral blood flow during intracarotid infusion of Y-26763 was measured in anesthetized SHRSP and normotensive Wistar-Kyoto rats (WKY) as control. Y-26763 increased cerebral blood flow in a dose-dependent manner in WKY, and glibenclamide, a selective inhibitor of ATP-sensitive potassium channels, inhibited the Y-26763-induced increase in cerebral blood flow. In contrast, the response to Y-26763 in SHRSP was significantly impaired compared with that in WKY. Antihypertensive treatment with cilazapril lowered blood pressure toward normal and prevented the impaired response in cerebral blood flow to Y-26763 in SHRSP. These findings suggest that (1) ATP-sensitive potassium channels contribute to the regulation of cerebral blood flow in rats, (2) the response to an ATP-sensitive potassium channel opener is markedly diminished in hypertensive rats, and (3) the altered response to an ATP-sensitive potassium channel opener during chronic hypertension can be prevented by long-term antihypertensive treatment.
AuthorsH Takaba, T Nagao, S Ibayashi, T Kitazono, K Fujii, M Fujishima
JournalHypertension (Dallas, Tex. : 1979) (Hypertension) Vol. 28 Issue 1 Pg. 143-6 (Jul 1996) ISSN: 0194-911X [Print] United States
PMID8675255 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive Agents
  • Benzopyrans
  • Hypoglycemic Agents
  • Potassium Channels
  • Cilazapril
  • Adenosine Triphosphate
  • Y 26763
  • Glyburide
Topics
  • Adenosine Triphosphate (metabolism)
  • Angiotensin-Converting Enzyme Inhibitors (pharmacology)
  • Animals
  • Antihypertensive Agents (administration & dosage, pharmacology)
  • Benzopyrans (pharmacology)
  • Blood Pressure
  • Cerebrovascular Circulation (drug effects)
  • Cilazapril (administration & dosage, pharmacology)
  • Female
  • Glyburide (pharmacology)
  • Hypertension (drug therapy, metabolism, physiopathology)
  • Hypoglycemic Agents (pharmacology)
  • Potassium Channels (drug effects, metabolism)
  • Rats
  • Rats, Inbred SHR
  • Rats, Inbred WKY
  • Time Factors

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