Abstract |
We examined whether the effect of Y-26763, an ATP-sensitive potassium channel opener, on cerebral blood flow is altered in stroke-prone spontaneously hypertensive rats (SHRSP) and, if altered, whether long-term antihypertensive treatment with cilazapril, an angiotensin-converting enzyme inhibitor, is capable of preventing the change. Cerebral blood flow during intracarotid infusion of Y-26763 was measured in anesthetized SHRSP and normotensive Wistar-Kyoto rats (WKY) as control. Y-26763 increased cerebral blood flow in a dose-dependent manner in WKY, and glibenclamide, a selective inhibitor of ATP-sensitive potassium channels, inhibited the Y-26763-induced increase in cerebral blood flow. In contrast, the response to Y-26763 in SHRSP was significantly impaired compared with that in WKY. Antihypertensive treatment with cilazapril lowered blood pressure toward normal and prevented the impaired response in cerebral blood flow to Y-26763 in SHRSP. These findings suggest that (1) ATP-sensitive potassium channels contribute to the regulation of cerebral blood flow in rats, (2) the response to an ATP-sensitive potassium channel opener is markedly diminished in hypertensive rats, and (3) the altered response to an ATP-sensitive potassium channel opener during chronic hypertension can be prevented by long-term antihypertensive treatment.
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Authors | H Takaba, T Nagao, S Ibayashi, T Kitazono, K Fujii, M Fujishima |
Journal | Hypertension (Dallas, Tex. : 1979)
(Hypertension)
Vol. 28
Issue 1
Pg. 143-6
(Jul 1996)
ISSN: 0194-911X [Print] United States |
PMID | 8675255
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Antihypertensive Agents
- Benzopyrans
- Hypoglycemic Agents
- Potassium Channels
- Cilazapril
- Adenosine Triphosphate
- Y 26763
- Glyburide
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Topics |
- Adenosine Triphosphate
(metabolism)
- Angiotensin-Converting Enzyme Inhibitors
(pharmacology)
- Animals
- Antihypertensive Agents
(administration & dosage, pharmacology)
- Benzopyrans
(pharmacology)
- Blood Pressure
- Cerebrovascular Circulation
(drug effects)
- Cilazapril
(administration & dosage, pharmacology)
- Female
- Glyburide
(pharmacology)
- Hypertension
(drug therapy, metabolism, physiopathology)
- Hypoglycemic Agents
(pharmacology)
- Potassium Channels
(drug effects, metabolism)
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY
- Time Factors
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