Abstract | OBJECTIVES: SETTING: University research laboratory. SUBJECTS: Twenty-one adult female Suffolk sheep, weighing 39 to 49 kg. INTERVENTIONS: MEASUREMENTS AND MAIN RESULTS: Serial hemodynamics, intracranial pressure, electrolytes, and osmolarity were measured. AT the end of resuscitation, the animals were killed and brain water content (mL H2O/g dry weight) of the injured and uninjured areas was determined. Resuscitation volumes were significantly lower in the isosal (19 +/- 5 mL/kg) and 7.5% hypertonic saline (14 +/- 2 mL/mg) groups compared with the lactated Ringer's solution (35 +/- 5 mL/kg) group. Intracranial pressure after 2 hrs of resuscitation was significantly lower in the isosal (7 +/- 1 mm Hg) and hypertonic saline groups (4 +/- 1 mm Hg). Water content in all areas of the brain was significantly lower in the hypertonic saline group compared with the lactated Ringer's solution group. Brain water content in the isosal group was lower than in the lactated Ringer's solution group only in the cerebellum. Plasma sodium content was lower in the isosal group than in the hypertonic saline group. CONCLUSIONS:
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Authors | A A Sheikh, T Matsuoka, D H Wisner |
Journal | Critical care medicine
(Crit Care Med)
Vol. 24
Issue 7
Pg. 1226-32
(Jul 1996)
ISSN: 0090-3493 [Print] United States |
PMID | 8674340
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hypertonic Solutions
- Isotonic Solutions
- Ringer's Solution
- Sodium
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Topics |
- Animals
- Brain
(drug effects)
- Craniocerebral Trauma
(complications, therapy)
- Female
- Hemodynamics
- Hypertonic Solutions
(analysis, pharmacology)
- Intracranial Pressure
- Isotonic Solutions
(pharmacology)
- Osmolar Concentration
- Prospective Studies
- Random Allocation
- Resuscitation
(methods)
- Ringer's Solution
- Sheep
- Shock, Hemorrhagic
(complications, therapy)
- Sodium
(analysis, blood)
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