H-cadherin, a novel cadherin with growth inhibitory functions and diminished expression in human breast cancer.

Abstract

A newly identified gene, H-cadherin, is reported. H-cadherin encodes a protein related to the cadherin superfamily of cell adhesion molecules, and its expression is shown to be significantly reduced in human breast carcinoma cell lines and breast cancer specimens. H-cadherin was localized to chromosome 16q24 and is highly expressed in the heart. Introduction of H-cadherin cDNA markedly diminished tumor cell growth and resulted in a significant change from invasive morphology to a normal cell-like morphology in the Matrigel outgrowth assay. These studies indicate that downregulation of H-cadherin may be frequent in the breast malignant progression and suggest that it may have prognostic value as a marker for breast cancer development.

• Authors: S W Lee
• Journal: Nature medicine (Nat Med) Vol. 2 Issue 7 Pg. 776-82 (Jul 1996) ISSN: 1078-8956 [Print] United States
• PMID: 8673923 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cadherins
• DNA, Complementary
• H-cadherin

Topics

• Amino Acid Sequence
• Breast Neoplasms (metabolism, pathology)
• Cadherins (genetics, metabolism)
• Cell Division
• Chromosome Mapping
• Chromosomes, Human, Pair 16
• Cloning, Molecular
• DNA, Complementary
• Humans
• Molecular Sequence Data
• Tumor Cells, Cultured