Abstract |
The efficacy of transdermal hyoscine in the reduction of nausea, retching and vomiting was compared with placebo during and after stapedo- and tympanoplasty under local anaesthesia in a double-blind, prospective and randomized study. In the placebo group (n = 29), 69% of the patients were free from emetic symptoms during and 41% after the operation. The corresponding figures were 93% (P < 0.05) and 74% (P < 0.05) in the hyoscine group (n = 27). The patients in the placebo group needed more droperidol during and after operation (P < 0.05). The frequency of side effects was similar in both groups. In posturography the patients with emetic sequelae in the placebo group had a markedly deteriorated upkeep of posture (P < 0.05) measured as body sway velocities. A strong correlation was found between motion sickness and emetic sequelae after surgery, and patients with a history of motion sickness benefited most from hyoscine.
|
Authors | P Honkavaara |
Journal | British journal of anaesthesia
(Br J Anaesth)
Vol. 76
Issue 1
Pg. 49-53
(Jan 1996)
ISSN: 0007-0912 [Print] England |
PMID | 8672379
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
|
Chemical References |
|
Topics |
- Administration, Cutaneous
- Adult
- Anesthesia, Local
- Antiemetics
(administration & dosage)
- Double-Blind Method
- Ear, Middle
(surgery)
- Female
- Humans
- Intraoperative Complications
(prevention & control)
- Male
- Middle Aged
- Nausea
(prevention & control)
- Postoperative Complications
(prevention & control)
- Posture
- Prospective Studies
- Scopolamine
(administration & dosage)
- Stapes Surgery
- Tympanoplasty
- Vomiting
(prevention & control)
|