Abstract | PURPOSE:
Radiotherapy, especially in the abdominal region, is frequently associated with gastrointestinal side effects. METHODS: The article reviews the current knowledge about pathophysiological background, clinical symptoms and the treatment strategies of the major gastrointestinal side effects. RESULTS: Several basics are investigated and depending on this knowledge some special treatment strategies have been developed ( 5-HT3-receptor-antagonists in the treatment of nausea, Figure 1, Table 2). The treatment of stomatitis, esophagitis, enteritis and proctitis still remains symptomatic and is not yet standardized (Tables 3 to 6). There are some promising results with smectit ( enteritis) and sucralfat. Special dental attendance should be performed before initiating radiotherapy of the head and neck region. Technical improvement in radiotherapy will also help to reduce side effects. CONCLUSION: In order to minimize gastrointestinal side effects, it is necessary to further investigate the pathophysiology of acute and late toxicity.
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Authors | F Paulsen, W Hoffmann, R D Kortmann, R Porschen, M Bamberg |
Journal | Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
(Strahlenther Onkol)
Vol. 172
Issue 2
Pg. 53-63
(Feb 1996)
ISSN: 0179-7158 [Print] Germany |
Vernacular Title | Akute gastrointestinale Nebenwirkungen in der Radioonkologie--Was ist gesichert in der Therapie? |
PMID | 8669046
(Publication Type: Case Reports, English Abstract, Journal Article, Review)
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Chemical References |
- Antiemetics
- Gastrointestinal Agents
- Silicates
- Sucralfate
- Smectite
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Topics |
- Abdominal Neoplasms
(radiotherapy)
- Acute Disease
- Antiemetics
(therapeutic use)
- Enteritis
(etiology, therapy)
- Esophagitis
(etiology, therapy)
- Female
- Gastrointestinal Agents
(therapeutic use)
- Gastrointestinal Diseases
(etiology, therapy)
- Humans
- Male
- Nausea
(drug therapy, etiology)
- Proctitis
(etiology, therapy)
- Radiation Injuries
(etiology, therapy)
- Radiotherapy
(adverse effects)
- Radiotherapy Dosage
- Silicates
- Stomatitis
(etiology, therapy)
- Sucralfate
(therapeutic use)
- Vomiting
(drug therapy, etiology)
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