Abstract |
Comparative mapping of the X chromosome in eutherian mammals has revealed distinct regions of conservation as well as evolutionary rearrangements between human and mouse. Recently, we and others mapped the murine homologue of CLCN4 ( Chloride channel 4) to band F4 of the X chromosome in Mus spretus but to chromosome 7 in laboratory strains. We now report the mapping of the murine homologues of APXL ( Apical protein Xenopus laevis-like) and OA1 ( Ocular albinism type I), two genes that are located on the human X chromosome at band p22. 3 and in close proximity to CLCN4. Interestingly, Oa1 and Apxl map to bands F2-F3 in both M. spretus and the laboratory strain C57BL/6J, defining a new rearrangement between human and mouse X chromosomes.
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Authors | M B Dinulos, M T Bassi, E I Rugarli, V Chapman, A Ballabio, C M Disteche |
Journal | Genomics
(Genomics)
Vol. 35
Issue 1
Pg. 244-7
(Jul 01 1996)
ISSN: 0888-7543 [Print] United States |
PMID | 8661129
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- CLC-5 chloride channel
- CLCN4 protein, human
- Chloride Channels
- Genetic Markers
- Membrane Proteins
- Microfilament Proteins
- SHROOM2 protein, human
- Shroom2 protein, mouse
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Topics |
- Albinism, Ocular
(genetics)
- Animals
- Chloride Channels
(genetics)
- Chromosome Mapping
- Crosses, Genetic
- Evolution, Molecular
- Gene Rearrangement
- Genetic Markers
- Humans
- Membrane Proteins
(genetics)
- Mice
(genetics)
- Mice, Inbred C57BL
- Microfilament Proteins
- Muridae
(genetics)
- Species Specificity
- X Chromosome
(genetics, ultrastructure)
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