[Immuno-contraceptive vaccines].

Abstract

Results of studies on birth control vaccines accomplished by many research groups within the WHO Special Programe of Research, Development and Research Training in Human Reproduction has been reviewed. The mostly investigated contraceptive vaccines contain human chorionic gonadotropin, and therefore structure, biological role and immunogenicity of the hormone were presented. Also, vaccines obtained on the basis of subunit beta of the human chorionic gonadotropin, its heterodimer with subunit beta of ovine lutropin or C-terminal peptide of beta subunit were described. Results of two phases of clinical trials with immuno-contraceptive vaccines were presented. The use of contraceptive vaccines for treatment of some trophoblastic tumors and the idea of using contraceptive recombinant vaccines were also mentioned.

• Authors: I E Kochanowska, A Szewczuk
• Journal: Postepy higieny i medycyny doswiadczalnej (Postepy Hig Med Dosw) Vol. 49 Issue 4 Pg. 451-68 ( 1995) ISSN: 0032-5449 [Print] Poland
• Vernacular Title: Szczepionki immunoantykoncepcyjne.
• PMID: 8657642 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Chorionic Gonadotropin
• Recombinant Proteins

Topics

• Animals
• Chorionic Gonadotropin (physiology)
• Contraception, Immunologic (methods)
• Female
• Humans
• Pregnancy
• Recombinant Proteins
• Trophoblastic Neoplasms (therapy)
• Uterine Neoplasms (therapy)