Cytomegalovirus glycoprotein B groups associated with retinitis in AIDS.

Abstract

To determine if cytomegalovirus (CMV) retinitis occurs more frequently in patients infected with certain strains CMV isolates from the blood of 44 patients with advanced human immunodeficiency virus disease were grouped by the DNA sequence or the restriction endonuclease digest pattern of a portion of the glycoprotein B (gB) gene. Forty-two patients (95%) were followed clinically until the development of CMV retinitis or death. Fourteen (78%; 95% confidence interval, 7%-39%) of 26 with isolates belonging to other gB groups developed CMV retinitis (P = .002). Viremia caused by gB group 2 CMV strains is associated with higher risk of CMV retinitis than viremia due to other CMV gB groups. The association of CMV gB gene with retinitis suggests this gene, or one linked to it, is a virulence factor for CMV strains causing infection in AIDS patients.

• Authors: D H Shepp, M E Match, A B Ashraf, S M Lipson, C Millan, R Pergolizzi
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 174 Issue 1 Pg. 184-7 (Jul 1996) ISSN: 0022-1899 [Print] United States
• PMID: 8655991 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Viral Envelope Proteins
• glycoprotein B, Simplexvirus

Topics

• AIDS-Related Opportunistic Infections (virology)
• Acquired Immunodeficiency Syndrome (etiology)
• Base Sequence
• Bone Marrow Transplantation
• Cytomegalovirus (classification, genetics, isolation & purification)
• Cytomegalovirus Infections (virology)
• Humans
• Molecular Sequence Data
• Retinitis (virology)
• Viral Envelope Proteins (genetics, isolation & purification)