Abstract | BACKGROUND: METHODS: RESULTS: Children who had not previously cried were more likely to cry when midazolam was administered compared with sufentanil (71% versus 20%, p = 0.0031). Of 31 midazolam patients, 20 experienced nasal irritation. Approximately 15 to 20 minutes after drug administration, most patients in both groups could be comfortably separated from their parents. The sufentanil group appeared to be more sedated and more cooperative during induction of anesthesia. Vital signs and oxygen saturation did not change significantly with either medication before or after surgery, although two sufentanil patients had a moderate reduction in ventilatory compliance after anesthetic induction. Sufentanil was associated with more nausea and vomiting than midazolam (34% versus 6%, p < 0.02). CONCLUSION:
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Authors | N Zedie, D W Amory, B K Wagner, D A O'Hara |
Journal | Clinical pharmacology and therapeutics
(Clin Pharmacol Ther)
Vol. 59
Issue 3
Pg. 341-8
(Mar 1996)
ISSN: 0009-9236 [Print] United States |
PMID | 8653997
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Adjuvants, Anesthesia
- Anti-Anxiety Agents
- Sufentanil
- Midazolam
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Topics |
- Adjuvants, Anesthesia
(administration & dosage, therapeutic use)
- Administration, Intranasal
- Ambulatory Surgical Procedures
- Anti-Anxiety Agents
(administration & dosage, therapeutic use)
- Child
- Child, Preschool
- Female
- Humans
- Infant
- Male
- Midazolam
(administration & dosage, therapeutic use)
- Single-Blind Method
- Sufentanil
(administration & dosage, therapeutic use)
- Treatment Outcome
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