CD30 ligand is expressed on resting normal and malignant human B lymphocytes.

Abstract

CD30, a member of the tumour necrosis receptor superfamily, is physiologically expressed on a subpopulation of T helper cells in normal individuals but is also expressed on several malignant and virally transformed cells. Its ligand (CD30L) is a pleiotropic cellular transmembrane protein that can induce cell death in several CD30+ cell lines. CD30L expression has been reported on activated human peripheral blood T lymphocytes and macrophages but not on B cells. Here we show that the CD30L is expressed on resting normal and on malignant B cells in addition to both CD4+ and CD8+ subsets of activated T cells, making it the second tumour necrosis family member, in addition to the CD27 ligand, that can be expressed on both T and B cells. These findings raise the possibility that the CD30L has a role in B-cell/T-cell communication and that B and T cells are likely to be involved in the growth regulation of CD30+ tumours.

• Authors: A Younes, U Consoli, S Zhao, V Snell, E Thomas, H J Gruss, F Cabanillas, M Andreeff
• Journal: British journal of haematology (Br J Haematol) Vol. 93 Issue 3 Pg. 569-71 (Jun 1996) ISSN: 0007-1048 [Print] England
• PMID: 8652374 (Publication Type: Journal Article)

Chemical References

• CD30 Ligand
• Ligands
• Membrane Glycoproteins
• RNA, Messenger
• TNFSF8 protein, human

Topics

• B-Lymphocytes (metabolism)
• Base Sequence
• CD30 Ligand
• Humans
• Ligands
• Membrane Glycoproteins (metabolism)
• Molecular Sequence Data
• Polymerase Chain Reaction
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (metabolism)
• RNA, Messenger (metabolism)