HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Clinical correlations with HLA type in Japanese patients with connective tissue disease and anti-U1 small nuclear RNP antibodies.

AbstractOBJECTIVE:
To elucidate the roles of HLA genes in the clinical presentation of patients with connective tissue disease and serum anti-U1 small nuclear RNP antibody.
METHODS:
HLA class I antigens and HLA class II alleles were determined in 43 Japanese patients with anti-U1 RNP antibody alone, by microcytotoxicity testing and DNA typing, respectively. Prospectively recorded clinical and laboratory features were analyzed in relation to HLA class I and class II types.
RESULTS:
DQB1*0303 was associated with lupus-related symptoms including fever, malar rash, oral ulcers, hypocomplementemia, and high-titer anti-double-stranded DNA antibody. Other HLA-clinical associations included DR2 with pleuritis, DR4 with hand swelling, and DRB1*0405 with arthritis.
CONCLUSION:
These HLA-clinical associations explain, in part, the heterogeneous clinical presentation in patients with anti-U1 RNP antibody.
AuthorsM Kuwana, Y Okano, J Kaburaki, H Inoko
JournalArthritis and rheumatism (Arthritis Rheum) Vol. 39 Issue 6 Pg. 938-42 (Jun 1996) ISSN: 0004-3591 [Print] United States
PMID8651987 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies
  • HLA Antigens
  • Ribonucleoprotein, U1 Small Nuclear
Topics
  • Adolescent
  • Adult
  • Alleles
  • Antibodies
  • Child
  • Connective Tissue Diseases (immunology)
  • Female
  • Genes, MHC Class I
  • Genes, MHC Class II
  • HLA Antigens (genetics)
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Prospective Studies
  • Ribonucleoprotein, U1 Small Nuclear (immunology)
  • Statistics as Topic

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: