Use of intravenous dofetilide in atrial flutter with hemodynamic instability.

Abstract	Paroxysmal atrial flutter is a drug-resistant supraventricular tachyarrhythmia that is often accompanied by hemodynamic instability due to an excessive ventricular response. We report here a case of atrial flutter with 1:1 atrioventricular conduction, in which we were able to rescue the patient from a state of cardiogenic shock by using intravenous dofetilide, a new class III antiarrhythmic agent. Dofetilide was suitable for the treatment because it immediately increased atrioventricular nodal refractoriness without any negative inotropic action.
Authors	A Kuruma, H Atarashi, T Ino, M Yashima, A Nomura, H Hayakawa
Journal	Japanese circulation journal (Jpn Circ J) Vol. 60 Issue 1 Pg. 67-9 (Jan 1996) ISSN: 0047-1828 [Print] Japan
PMID	8648886 (Publication Type: Case Reports, Journal Article)
Chemical References	Anti-Arrhythmia Agents Phenethylamines Sulfonamides dofetilide
Topics	Adult Anti-Arrhythmia Agents (administration & dosage) Atrial Flutter (drug therapy, physiopathology) Blood Pressure Female Heart Rate Humans Injections, Intravenous Phenethylamines (administration & dosage) Sulfonamides (administration & dosage)

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