Detection of IL-5 and IL-1 receptor antagonist in bronchoalveolar lavage fluid in acute eosinophilic pneumonia.

Abstract

BACKGROUND:

Acute eosinophilic pneumonia is an idiopathic cause of respiratory failure, characterized by very high numbers of alveolar eosinophils without significant blood eosinophilia.

OBJECTIVE:

The purpose of this study was to determine which cytokines are associated with acute eosinophilic pneumonia.

METHODS:

Soluble IL-1 type II receptor and the cytokines IL-1 beta, IL-1ra, IL-3, IL-5, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor-alpha were measured in serum and in bronchoalveolar lavage fluid from two patients with acute eosinophilic pneumonia during both acute and convalescent phases.

RESULTS:

Compared with patients with adult respiratory distress syndrome, the patients with acute eosinophilic pneumonia had high bronchoalveolar lavage fluid levels of IL-5, IL-1ra, and soluble type II IL-1 receptor but not IL-1 beta, tumor necrosis factor-alpha, IL-3, or granulocyte-macrophage colony-stimulating factor. Bronchoalveolar lavage fluid levels of IL-5 and IL-1ra fell after resolution of symptoms. In the serum of patients with acute eosinophilic pneumonia, IL-5 was not detectable, and IL-1ra was initially high but fell after corticosteroid treatment.

CONCLUSION:

Acute eosinophilic pneumonia is characterized by locally high levels of IL-5, IL-1ra, and soluble type II IL-1 receptor in the alveolar space.

• Authors: J N Allen, Z Liao, M D Wewers, E A Altenberger, S A Moore, E D Allen
• Journal: The Journal of allergy and clinical immunology (J Allergy Clin Immunol) Vol. 97 Issue 6 Pg. 1366-74 (Jun 1996) ISSN: 0091-6749 [Print] United States
• PMID: 8648034 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cytokines
• IL1RN protein, human
• Interleukin 1 Receptor Antagonist Protein
• Interleukin-5
• Sialoglycoproteins

Topics

• Acute Disease
• Adolescent
• Bronchoalveolar Lavage Fluid (chemistry)
• Cytokines (metabolism)
• Female
• Humans
• Interleukin 1 Receptor Antagonist Protein
• Interleukin-5 (metabolism)
• Leukocyte Count
• Male
• Middle Aged
• Pulmonary Alveoli (metabolism)
• Pulmonary Eosinophilia (metabolism)
• Respiratory Distress Syndrome (metabolism)
• Sialoglycoproteins (metabolism)