Human chorionic gonadotropin produced by ectopic pinealoma in a girl with precocious puberty. Case report.

Abstract

A case is reported in which a human chorionic gonadotropin (HCG-)-producing ectopic pinealoma was found in a 5-year-old girl with precocious puberty. Physical examination revealed abnormal breast enlargement. Endocrinological study disclosed a high plasma HCG concentration of 1192 ng/ml with a normal follicular stimulating hormone (FSH) level. The HCG content of the tumor was as high as 400 ng/mg of acetone dried tissue, but no FSH was detectable. This is the first reported case of precocious puberty associated with pineal tumor in a female.

• Authors: O Kubo, N Yamasaki, Y Kamijo, K Amano, K Kitamura, R Demura
• Journal: Journal of neurosurgery (J Neurosurg) Vol. 47 Issue 1 Pg. 101-5 (Jul 1977) ISSN: 0022-3085 [Print] United States
• PMID: 864495 (Publication Type: Case Reports, Journal Article)

Chemical References

• Chorionic Gonadotropin
• Hormones, Ectopic
• Prolactin
• Luteinizing Hormone
• Follicle Stimulating Hormone

Topics

• Cerebral Ventricle Neoplasms (metabolism, ultrastructure)
• Child, Preschool
• Chorionic Gonadotropin (biosynthesis)
• Female
• Follicle Stimulating Hormone (metabolism)
• Hormones, Ectopic (biosynthesis)
• Humans
• Luteinizing Hormone (metabolism)
• Pinealoma (metabolism, ultrastructure)
• Prolactin (metabolism)
• Puberty, Precocious (etiology)