Abstract |
Ethyl-6-ethoxybenzothiazole-2-carbamate ( Sch 18099) was evaluated for efficacy against natural helminth infections in ponies, pigs, lambs and chickens. Sixteen critical trials were conducted in ponies at dosages of 15 to 150 mg/kg. At 15 mg/kg, efficacy against adult and larval Oxyuris equi was 100% and 91% and against small strongyles it was 98%. Efficacy levels were 95% against Strongylus vulgaris and S. edentatus at the 20 mg/kg dosage. In two trials at 100 mg/kg efficacy against Parascaris equorum was 77%. No efficacy was observed against Gastrophilus spp. or Anoplocephala spp. In swine single oral doses of 10 to 100 mg/kg were not effective. 500 ppm Sch 18099 in the diet for seven days resulted in 100% efficacy against Ascaris suum and Trichuris suis but had no effect on Stongyloides ransomi. Efficacy at 250 ppm against A. suum was 77%. Efficacy at 200 mg/kg in lambs was greater than 90% for Haemonchus contortus, Trichostrongylus axei, Marshallagia marshalli, Bunostomum trignocephalum, Oesophagostomum columbianum, Trichuris ovis, and Chabertia spp. Efficacy was less than 80% for Trichostrongylus vitrinus, Nematodirus filicollis, Ostertagia circumcinta and Cooperia curticei. Except for O. circumcinta and C. curticei, drug efficacy was reduced for these worms in lambs treated at 100 mg/kg. Efficacies of 14.3-89% against Ascaridia galli were obtained with dietary levels of 125-1000 ppm Sch 18099 fed for 7 days. Efficacy of 100% was recorded against Heterakis gallinarum at the 1000 ppm dietary drug level.
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Authors | E Panitz |
Journal | Journal of helminthology
(J Helminthol)
Vol. 51
Issue 1
Pg. 23-30
(Mar 1977)
ISSN: 0022-149X [Print] England |
PMID | 864223
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Anthelmintics
- Carbamates
- Thiazoles
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Topics |
- Animals
- Animals, Domestic
- Anthelmintics
(therapeutic use)
- Ascariasis
(drug therapy, veterinary)
- Carbamates
(therapeutic use)
- Chickens
- Horses
- Nematode Infections
(drug therapy, veterinary)
- Poultry Diseases
(drug therapy)
- Sheep
- Sheep Diseases
(drug therapy)
- Strongyle Infections, Equine
(drug therapy)
- Swine
- Swine Diseases
(drug therapy)
- Thiazoles
(therapeutic use)
- Trichuriasis
(drug therapy, veterinary)
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