Abstract | OBJECTIVE: DESIGN: Clinical trial. ANIMALS: 127 cows with urine acetoacetate concentration > or = 60 mg/dl. PROCEDURE: Cows were treated with 500 ml of 50% glucose solution. IV, and 40 mg of dexamethasone, IM (group 1), 40 mg of dexamethasone, IM (group 2), 5 mg of flumethasone (group 3), or 500 ml of 50% glucose solution, IV, and 5 mg of flumethasone (group 4). Treatment success was defined as recovery after a single treatment without relapse during the same lactation. Uterine disease ( retained placenta or metritis), parity, and pretreatment plasma glucose, serum beta-hydroxybutyric acid, and urine acetoacetate concentrations were evaluated as possible confounding factors affecting recovery. RESULTS: Only uterine disease was found to have a significant effect on recovery. Treatments 1 and 4 were significantly more efficacious than was treatment 2, but efficacy of treatment 2 was not significantly different from that of treatment 3. Regardless of treatment, cows with uterine disease were less likely to have a successful outcome than were cows without uterine disease. In all treatment groups, plasma glucose concentration increased and serum beta-hydroxybutyric acid and urine acetoacetate concentrations decreased following treatment. CLINICAL IMPLICATIONS: In this study, treatment of ketosis in dairy cattle with a corticosteriod alone was less efficacious than treatment with glucose and a corticosteroid.
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Authors | N Y Shpigel, R Chen, Y Avidar, E Bogin |
Journal | Journal of the American Veterinary Medical Association
(J Am Vet Med Assoc)
Vol. 208
Issue 10
Pg. 1702-4
(May 15 1996)
ISSN: 0003-1488 [Print] United States |
PMID | 8641955
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Acetoacetates
- Blood Glucose
- Glucocorticoids
- Hydroxybutyrates
- Solutions
- Dexamethasone
- Glucose
- Flumethasone
- 3-Hydroxybutyric Acid
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Topics |
- 3-Hydroxybutyric Acid
- Acetoacetates
(urine)
- Animals
- Blood Glucose
(analysis)
- Cattle
- Cattle Diseases
(drug therapy)
- Dexamethasone
(administration & dosage, therapeutic use)
- Drug Therapy, Combination
- Female
- Flumethasone
(administration & dosage, therapeutic use)
- Glucocorticoids
(administration & dosage, therapeutic use)
- Glucose
(administration & dosage, therapeutic use)
- Hydroxybutyrates
(blood)
- Infusions, Intravenous
(veterinary)
- Injections, Intramuscular
(veterinary)
- Ketosis
(drug therapy, veterinary)
- Lactation
- Odds Ratio
- Regression Analysis
- Solutions
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