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Effect of aluminum hydroxide/magnesium hydroxide antacid and bismuth subsalicylate on gastric pH in horses.

AbstractOBJECTIVE:
To assess the effect of aluminum hydroxide/magnesium hydroxide antacid and bismuth subsalicylate on gastric pH in clinically normal horses and to develop guidelines on the use of these agents for treatment of peptic ulcer disease in horses.
DESIGN:
Prospective, randomized, controlled trial.
ANIMALS:
5 clinically normal adult horses with chronically implanted gastric cannulas.
PROCEDURE:
Each horse received all 5 treatments (30 g of aluminum hydroxide/15 g of magnesium hydroxide, 12 g of aluminum hydroxide/6 g of magnesium hydroxide, 10.5 g of bismuth subsalicylate, 26.25 g of bismuth subsalicylate, and 5% methylcellulose control) with only 1 experiment performed each day. Gastric pH was measured via a glass electrode inserted through the gastric cannula for 1 hour before treatment and continued for 2 hours after treatment. Food or water was not given to the horses during the experiment. Measurements of gastric pH obtained during posttreatment hours were compared with pretreatment gastric pH values.
RESULTS:
Only a dose of 30 g of aluminum hydroxide/ 15 g of magnesium hydroxide resulted in a significant increase in gastric pH over baseline or control values. Mean pH was 5.2 +/- 0.62 and 4.59 +/- 0.48 for posttreatment hours 1 and 2, respectively.
CLINICAL IMPLICATIONS:
Oral administration of 30 g of aluminum hydroxide/15 g of magnesium hydroxide to adult horses should result in a mean hourly gastric pH > or = 4.0 for at least 2 hours.
AuthorsC K Clark, A M Merritt, J A Burrow, C K Steible
JournalJournal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 208 Issue 10 Pg. 1687-91 (May 15 1996) ISSN: 0003-1488 [Print] United States
PMID8641951 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Antacids
  • Organometallic Compounds
  • Salicylates
  • Aluminum Hydroxide
  • bismuth subsalicylate
  • Magnesium Hydroxide
  • Bismuth
Topics
  • Administration, Oral
  • Aluminum Hydroxide (administration & dosage, pharmacology, therapeutic use)
  • Animals
  • Antacids (administration & dosage, pharmacology, therapeutic use)
  • Bismuth (administration & dosage, pharmacology, therapeutic use)
  • Drug Therapy, Combination
  • Female
  • Gastric Acidity Determination (veterinary)
  • Gastric Mucosa (metabolism)
  • Horse Diseases (drug therapy)
  • Horses (metabolism)
  • Hydrogen-Ion Concentration
  • Magnesium Hydroxide (administration & dosage, pharmacology, therapeutic use)
  • Male
  • Organometallic Compounds (administration & dosage, pharmacology, therapeutic use)
  • Peptic Ulcer (drug therapy, veterinary)
  • Prospective Studies
  • Salicylates (administration & dosage, pharmacology, therapeutic use)
  • Stomach (drug effects)

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