Lack of constitutive activation of Janus kinases and signal transduction and activation of transcription factors in Philadelphia chromosome-positive acute lymphoblastic leukemia.

Authors	V S Kanwar, B Witthuhn, D Campana, J N Ihle
Journal	Blood (Blood) Vol. 87 Issue 11 Pg. 4911-2 (Jun 01 1996) ISSN: 0006-4971 [Print] United States
PMID	8639867 (Publication Type: Letter, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References	DNA-Binding Proteins Milk Proteins Neoplasm Proteins Proteins Proto-Oncogene Proteins STAT5 Transcription Factor Trans-Activators Protein-Tyrosine Kinases Fusion Proteins, bcr-abl JAK1 protein, human JAK2 protein, human JAK3 protein, human Janus Kinase 1 Janus Kinase 2 Janus Kinase 3 TYK2 Kinase TYK2 protein, human
Topics	DNA-Binding Proteins (metabolism) Enzyme Activation Fusion Proteins, bcr-abl (metabolism) Gene Expression Regulation, Leukemic Humans Janus Kinase 1 Janus Kinase 2 Janus Kinase 3 Milk Proteins Neoplasm Proteins (metabolism) Phosphorylation Precursor Cell Lymphoblastic Leukemia-Lymphoma (enzymology, genetics, pathology) Protein Processing, Post-Translational Protein-Tyrosine Kinases (metabolism) Proteins (metabolism) Proto-Oncogene Proteins STAT5 Transcription Factor Signal Transduction TYK2 Kinase Trans-Activators (metabolism) Tumor Cells, Cultured

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!