| Abstract | A 42-year-old woman with liver metastasis from adrenal cortical carcinoma was treated with mitotane (o,p'DDD) for 11 months with a minimal response. Mitotane was stopped because of severe adverse effects. Thereafter a combination of cisplatin and etoposide was given every 3 weeks. A partial response was achieved after five chemotherapy courses. Following this chemotherapy, the patient had a surgical excision of the liver metastasis and entered into a complete remission for 17 months. Etoposide plus cisplatin may be an active combination for the treatment of adrenal cortical carcinoma. |
| Authors | J Zidan, M Shpendler, E Robinson
(Affiliation: Northern Israel Oncology Center, Rambam Medical Center, Endocrinology Unit, Bnei-Zion Hospital, Haifa, Israel.)
|
| Journal | American journal of clinical oncology
(Am J Clin Oncol)
Vol. 19
Issue 3
Pg. 229-31
(Jun 1996)
ISSN: 0277-3732 UNITED STATES |
| PMID | 8638530
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
- Antineoplastic Agents, Hormonal
- Cisplatin
- Etoposide
- Mitotane
|
| Topics |
- Adrenal Cortex Neoplasms
(pathology)
- Adult
- Antineoplastic Agents, Hormonal
(adverse effects, therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Carcinoma
(drug therapy, secondary, surgery)
- Cisplatin
(administration & dosage)
- Etoposide
(administration & dosage)
- Female
- Humans
- Liver Neoplasms
(drug therapy, secondary, surgery)
- Mitotane
(adverse effects, therapeutic use)
|
