Abstract |
The effect of one week of treatment with naproxen on the formation of heterotopic ossification after cemented total hip arthroplasty was studied in a prospective trial. Twenty-seven patients received 500 mg naproxen twice daily for seven days postoperatively. The medication was started on the morning of the operation. The results were compared to a control group of 23 patients from a previous study who had not received any kind of nonsteroidal anti-inflammatory drug. All radiographs were randomly mixed and patient identification was blinded. Three months after the operation 12/23 patients in the control group and 3/27 in the naproxen-treated group had developed heterotopic ossification. One year after the operation 4/27 in the naproxen-treated group and 12/23 in the control group had heterotopic ossification (p < 0.05). Three patients in the control group and none in the naproxen-treated group developed severe ossification. It is concluded that naproxen given for one week can decrease the incidence of heterotopic ossification after total hip arthroplasty.
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Authors | P H Gebuhr, H Wilbek, M Soelberg |
Journal | Ugeskrift for laeger
(Ugeskr Laeger)
Vol. 158
Issue 8
Pg. 1076-8
(Feb 19 1996)
ISSN: 0041-5782 [Print] Denmark |
Vernacular Title | Otte dages behandling med naproxen kan forebygge heterotop forkalkning efter total hoftealloplastik. |
PMID | 8638341
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Naproxen
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Topics |
- Aged
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage)
- Female
- Hip Prosthesis
(adverse effects)
- Humans
- Male
- Middle Aged
- Naproxen
(administration & dosage)
- Ossification, Heterotopic
(diagnostic imaging, etiology, prevention & control)
- Postoperative Complications
(diagnostic imaging, prevention & control)
- Radiography
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