[The action of medichronal (glucose-glycine-formate) on the serotonin blood level in alcoholism patients].

Abstract

The effects of a novel antialcoholic medication medichronal on the serotonine concentration in blood of patients with second stage alcoholism was investigated. It has been discovered that remission in 75% of the patients was connected with its hyper- and hyposerotoninemic influence, depending on the initial lowered or increased serotonine content. Similarity of medichronal and unithiol effects was observed in the form of palyndromoinversion regulation of serotoninergic activity. In a portion of the patients the increased, compared to healthy persons, serotonine concentration before and after the treatment does not differ from the average values in the whole group.

• Authors: G Kh Bozhko, P V Voloshin, L S Kostiukovskaia, L M Markozova, Z N Bolotova
• Journal: Likars'ka sprava (Lik Sprava) 1995 May-Jun Issue 5-6 Pg. 130-2 ISSN: 1019-5297 [Print] Ukraine
• Vernacular Title: Deĭstvie medikhronala (gliukozoglitsinformiata) na soderzhanie serotonina v krovi bol'nykh alkogolizmom.
• PMID: 8630781 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Alcohol Deterrents
• Drug Combinations
• Formates
• medikhronal
• Serotonin
• Unithiol
• Acetaldehyde
• Glucose
• Glycine

Topics

• Acetaldehyde (antagonists & inhibitors)
• Adult
• Alcohol Deterrents (therapeutic use)
• Alcoholism (blood, drug therapy)
• Drug Combinations
• Drug Evaluation
• Formates (therapeutic use)
• Glucose (therapeutic use)
• Glycine (therapeutic use)
• Humans
• Male
• Serotonin (blood)
• Unithiol (therapeutic use)