[The value of determining neuron specific enolase for diagnosis of complete remission during treatment of small cell lung cancer].

Abstract

The aim of this study was to assess whether the lowest serum NSE obtained during treatment of small cell lung cancer patients can be helpful in the diagnosis of complete remission (CR). The material consisted of 68 patients with small cell lung cancer, treated in the Institute o Tuberculosis and Lung Diseases from 1.III.1993 to 15.II.1995. In the course of treatment CR was obtained in 13 patients, partial remission (PR) in 37 and no remission (NR) in 18. The distribution and median of the lowest NSE serum levels were the same in CR and RP patients. NSE serum levels remained above normal, that is above 12.5 ng/ml, in two CR patients and in 4 PR patients. 3 patients (2 with CR and I with PR) are still living for 26, 27 and 41 months in spite of NSE serum levels 14.3, 15.6 and 13.6 ng/ml respectively. In those patients in whom NR was obtained the lowest NSE level above 20 ng/l was connected with bad prognosis. We conclude that the estimation of the lowest NSE serum level in the course of treatment can not help to differentiate CR from PR.

• Authors: E Rowińska-Zakrzewska, M Szturmowicz, E Wiatr, A Sakowicz, L Pawlicka, P Remiszewski, J Szopiński, J Zych, E Radzikowska
• Journal: Pneumonologia i alergologia polska (Pneumonol Alergol Pol) Vol. 64 Issue 1-2 Pg. 19-23 ( 1996) ISSN: 0867-7077 [Print] Poland
• Vernacular Title: Wartość oznaczania neuroswoistej enolazy NSE dla rozpoznania remisji całkowitej w przebiegu leczenia drobnokomórkowego raka płuca.
• PMID: 8630460 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Phosphopyruvate Hydratase

Topics

• Adult
• Aged
• Biomarkers, Tumor (blood)
• Carcinoma, Small Cell (diagnosis, therapy)
• Disease-Free Survival
• Female
• Humans
• Lung Neoplasms (diagnosis, therapy)
• Male
• Middle Aged
• Phosphopyruvate Hydratase (blood)
• Remission Induction