Abstract |
The purpose of this study was to evaluate the effects of mannitol (Man), dexamethasone (DM), dichloroacetic acid (DCA) and 1,3-butanediol (BD) in reduction of posttraumatic cortical edema following brain deformation injury to rats. Ten minutes prior to fluid percussion injury, each animal received one of four pretreatments or placebo: Man, 1 g/kg intravenously, DM 3.0 mg/kg intravenously, DCA 25 mg/kg intraperitoneally BD 0.5 mg/kg intraperitoneally (n = 12 per treatment group), or equivolume saline (n = 8 per corresponding trauma group). Six hours after trauma, cortical tissue was harvested. Using a benzene- kerosene gradient column calibrated with potassium sulfate standards, the specific gravity (SpG) of cortical tissue from each group was measured and compared (ANOVA, P < .05). The measured cortical SpG from traumatized animals receiving Man (mean 1.037 +/- SEM .001), DCA (1.038 +/- .001), and BD (1.039 +/- .001) were equal to SpG from untraumitized cortex (1.041 +/- .001), and were significantly greater than SpG from traumatized cortex for animals receiving DM (1.035 +/- .001) or placebo (1.033 +/- .002). Pretreatment with DCA, Man, and BD appears to protect against development of posttraumatic cortical edema when measured 6 hours after blunt head trauma in the rat. Each of these chemical treatments appears effective in preventing or reducing posttraumatic cortical edema.
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Authors | M H Biros, R Nordness |
Journal | The American journal of emergency medicine
(Am J Emerg Med)
Vol. 14
Issue 1
Pg. 27-32
(Jan 1996)
ISSN: 0735-6757 [Print] United States |
PMID | 8630150
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Butylene Glycols
- Diuretics, Osmotic
- Mannitol
- 1,3-butylene glycol
- Dexamethasone
- Dichloroacetic Acid
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Topics |
- Animals
- Anti-Inflammatory Agents
(therapeutic use)
- Brain Edema
(drug therapy, etiology)
- Brain Injuries
(complications)
- Butylene Glycols
(therapeutic use)
- Dexamethasone
(therapeutic use)
- Dichloroacetic Acid
(therapeutic use)
- Diuretics, Osmotic
(therapeutic use)
- Drug Evaluation, Preclinical
- Humans
- Male
- Mannitol
(therapeutic use)
- Premedication
(methods)
- Rats
- Rats, Sprague-Dawley
- Specific Gravity
- Time Factors
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