Abstract | STUDY OBJECTIVE: DESIGN: Thirty-two week, double-blind, randomized, placebo-controlled cross-over study. SETTING: A university outpatient pulmonary clinic. PARTICIPANTS: Twenty-six adults with stable chronic bronchitis completed the study; 28 completed the first treatment arm. INTERVENTIONS: Sixteen weeks each of placebo or IG 60 mg qid. MEASUREMENTS: First, pulmonary function by spirometry and plethysmography. Second, symptom score measured using a questionnaire. Third, sputum bulk and surface rheology, spinnability, mucociliary transportability and cough transportability. RESULTS: There were no significant changes in pulmonary function, clinical scores, or sputum properties related to therapy with IG. There was a significant improvement in the Global Petty score after both IG (p = 0.01) and placebo (p < 0.01) when compared with baseline, but there was no difference between treatment periods. There was a positive correlation between changes in the Global score during therapy and changes in sputum spinnability (p < 0.01, r = 0.38). CONCLUSIONS: This study clearly demonstrates that in chronic bronchitis, 16 weeks of therapy with IG does not produce any appreciable effect on pulmonary function, well being, or on sputum viscoelasticity or clearability.
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Authors | B K Rubin, O Ramirez, J A Ohar |
Journal | Chest
(Chest)
Vol. 109
Issue 2
Pg. 348-52
(Feb 1996)
ISSN: 0012-3692 [Print] United States |
PMID | 8620704
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Expectorants
- iodinated glycerol
- Glycerol
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Topics |
- Adult
- Bronchitis
(drug therapy, physiopathology)
- Chronic Disease
- Cross-Over Studies
- Double-Blind Method
- Expectorants
(pharmacology, therapeutic use)
- Glycerol
(analogs & derivatives, pharmacology, therapeutic use)
- Humans
- Lung
(drug effects)
- Respiratory Function Tests
- Surveys and Questionnaires
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