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Expression of Hel-N1 and Hel-N2 in small-cell lung carcinoma.

Abstract
Hel-N1 and HuD are neuron-specific RNA-binding proteins that are antigenic targets of anti-Hu antibodies. Although expression of Hu antigens is most commonly seen in small-cell lung carcinoma, their exact identity (e.g., Hel-NI, Hel-N2, HuD, and HuC cannot be distinguished by immunological methods. Analysis of messenger RNA expression is needed for this distinction. Here we demonstrate that Hel-NI and Hel-N2 are expressed in small-cell lung carcinoma using reverse transcription-polymerase chain reaction.
AuthorsP H King, E J Dropcho
JournalAnnals of neurology (Ann Neurol) Vol. 39 Issue 5 Pg. 679-81 (May 1996) ISSN: 0364-5134 [Print] United States
PMID8619556 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • DNA Primers
  • ELAV Proteins
  • ELAV-Like Protein 2
  • ELAV-Like Protein 4
  • ELAVL2 protein, human
  • ELAVL4 protein, human
  • Nerve Tissue Proteins
  • RNA-Binding Proteins
Topics
  • Base Sequence
  • Carcinoma, Small Cell (genetics)
  • DNA Primers (genetics)
  • ELAV Proteins
  • ELAV-Like Protein 2
  • ELAV-Like Protein 4
  • Gene Expression Regulation, Neoplastic (physiology)
  • Humans
  • Isomerism
  • Leukemia, Erythroblastic, Acute
  • Lung Neoplasms (genetics)
  • Molecular Sequence Data
  • Nerve Tissue Proteins (genetics)
  • Polymerase Chain Reaction
  • RNA-Binding Proteins (genetics)
  • Tumor Cells, Cultured (physiology)

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