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Anti-GD1a ganglioside antibodies in peripheral motor syndromes.

Abstract
High titers of anti-GD1a antibodies have been found in patients with Guillain-Barre syndrome or motor neuropathy. To determine the possible diagnostic relevance of these antibodies, we measured serum anti-GD1a IgG and IgM antibodies by enzyme-linked immunosorbent assay in 195 patients with different motor syndromes and in 335 control subjects. Moderately high antibody titers (1/1,280-1/5,120) were occasionally found in patients with chronic inflammatory demyelinating polyneuropathy (5%), multifocal motor neuropathy (18%), lower motor neuron disease (3.8%), or amyotrophic lateral sclerosis (1.8%) and in immunological control subjects (1.2%), while titers of 1/20,480 or higher were only found in 2 patients with Guillain-Barre syndrome (IgG in both) and 2 with motor neuropathy and IgM lambda monoclonal gammopathy improving with immunotherapy. In both motor neuropathy patients and the Guillain-Barre syndrome patient who were retested during recovery, anti-GD1a titers decreased concomitantly with clinical improvement. High anti-GD1a antibody titers may be found in several motor syndromes but only markedly increased anti-GD1a titers are strictly associated with potentially treatable dysimmune neuropathies.
AuthorsM Carpo, E Nobile-Orazio, N Meucci, M Gamba, S Barbieri, S Allaria, G Scarlato
JournalAnnals of neurology (Ann Neurol) Vol. 39 Issue 4 Pg. 539-43 (Apr 1996) ISSN: 0364-5134 [Print] United States
PMID8619533 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies
  • Gangliosides
  • Immunoglobulin G
  • Immunoglobulin M
  • ganglioside, GD1a
Topics
  • Aged
  • Antibodies (analysis)
  • Chromatography, Thin Layer
  • Demyelinating Diseases (immunology)
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Gangliosides (immunology)
  • Humans
  • Immunoglobulin G (analysis)
  • Immunoglobulin M (analysis)
  • Middle Aged
  • Neuromuscular Diseases (immunology, physiopathology)
  • Peripheral Nervous System Diseases (immunology)
  • Polyradiculoneuropathy (immunology)

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