Abstract |
High titers of anti-GD1a antibodies have been found in patients with Guillain-Barre syndrome or motor neuropathy. To determine the possible diagnostic relevance of these antibodies, we measured serum anti-GD1a IgG and IgM antibodies by enzyme-linked immunosorbent assay in 195 patients with different motor syndromes and in 335 control subjects. Moderately high antibody titers (1/1,280-1/5,120) were occasionally found in patients with chronic inflammatory demyelinating polyneuropathy (5%), multifocal motor neuropathy (18%), lower motor neuron disease (3.8%), or amyotrophic lateral sclerosis (1.8%) and in immunological control subjects (1.2%), while titers of 1/20,480 or higher were only found in 2 patients with Guillain-Barre syndrome ( IgG in both) and 2 with motor neuropathy and IgM lambda monoclonal gammopathy improving with immunotherapy. In both motor neuropathy patients and the Guillain-Barre syndrome patient who were retested during recovery, anti-GD1a titers decreased concomitantly with clinical improvement. High anti-GD1a antibody titers may be found in several motor syndromes but only markedly increased anti-GD1a titers are strictly associated with potentially treatable dysimmune neuropathies.
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Authors | M Carpo, E Nobile-Orazio, N Meucci, M Gamba, S Barbieri, S Allaria, G Scarlato |
Journal | Annals of neurology
(Ann Neurol)
Vol. 39
Issue 4
Pg. 539-43
(Apr 1996)
ISSN: 0364-5134 [Print] United States |
PMID | 8619533
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies
- Gangliosides
- Immunoglobulin G
- Immunoglobulin M
- ganglioside, GD1a
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Topics |
- Aged
- Antibodies
(analysis)
- Chromatography, Thin Layer
- Demyelinating Diseases
(immunology)
- Enzyme-Linked Immunosorbent Assay
- Female
- Gangliosides
(immunology)
- Humans
- Immunoglobulin G
(analysis)
- Immunoglobulin M
(analysis)
- Middle Aged
- Neuromuscular Diseases
(immunology, physiopathology)
- Peripheral Nervous System Diseases
(immunology)
- Polyradiculoneuropathy
(immunology)
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