[Droxicam-induced toxic hepatitis].

Abstract

We present four cases of hepatitis with clinical features indicating a direct link with Droxicam. In all the cases, the presentation was that of acute hepatitis with subsequent resolution, whereas one patient developed autoimmune chronic active hepatitis. A full evaluation including ultrasound, liver biopsy, and serologic markers supported the diagnosis. Due to the fact that the "Dirección General de Farmacia y Productos Sanitarios" has approved the postponement of dispensation of products with Droxicam from February 25, 1995, this drug should not be considered anymore in the future as a potential cause of liver injury (acute or chronic hepatitis).

• Authors: M Berenguer, F Pérez-Aguilar, C Gisbert, L A Ferreres, F J Vera-Sempere, J Berenguer
• Journal: Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva (Rev Esp Enferm Dig) Vol. 88 Issue 1 Pg. 49-52 (Jan 1996) ISSN: 1130-0108 [Print] Spain
• Vernacular Title: Hepatitis tóxica por Droxicam.
• PMID: 8616003 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Pyridines
• droxicam

Topics

• Adult
• Aged
• Anti-Inflammatory Agents, Non-Steroidal (adverse effects)
• Chemical and Drug Induced Liver Injury (etiology, pathology)
• Female
• Humans
• Liver (pathology)
• Male
• Middle Aged
• Pyridines (adverse effects)