[Basal levels of blood pepsinogen I and Helicobacter pylori infection in patients with duodenal ulcer and normal endoscopy].

To study basal pepsinogen I levels in patients with duodenal ulcer and in subjects with normal endoscopy, depending on Helicobacter pylori status.
One-hundred and one patients with duodenal ulcer and 74 controls with normal endoscopy were studied. Mean age and gender distribution were: 46 vs 42 years, and 74% vs 43% males, respectively. At endoscopy biopsies from the gastric antrum and body were obtained for histologic (H&E) and microbiologic (Gram and culture) study. Basal levels of serum pepsinogen I were measured (RIA).
Among the subjects with a normal endoscopy, those with H. pylori infection had higher pepsinogen I levels (m +/- SD) than non-infected patients (77 +/- 27 vs 62 +/- 28 ng/ml; p < 0.05). Basal levels in duodenal ulcer patients were 107 +/- 38 ng/ml, higher (p < 0.001) than in the group with normal endoscopy (both with and without H. pylori). In multivariate analysis pepsinogen I levels were correlated with H. pylori infection (regression coef.= 17; SE= 8.1), duodenal ulcer (regr. coef.= 22; SE= 5.8) and smoking habit (regr. coef.= 24; SE= 5.2).
Basal pepsinogen I levels were significantly higher in duodenal ulcer patients than in H. pylori infected subjects with normal endoscopy. The lowest levels corresponded to non-infected patients. Therefore, an additional factor other than H. pylori infection is likely involved in the hyperpepsinogenemia classically reported in duodenal ulcer patients.
AuthorsJ P Gisbert, D Boixeda, T Vila, L de Rafael, C Redondo, C Martín de Argila, C Arocena
JournalRevista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva (Rev Esp Enferm Dig) Vol. 88 Issue 1 Pg. 3-8 (Jan 1996) ISSN: 1130-0108 [Print] SPAIN
Vernacular TitleNiveles basales de pepsinógeno I sérico e infección por Helicobacter pylori en pacientes con úlcera duodenal y endoscopia normal.
PMID8615998 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Pepsinogens
  • Adult
  • Aged
  • Data Interpretation, Statistical
  • Duodenal Ulcer (blood, diagnosis)
  • Endoscopy
  • Female
  • Gastritis (blood, diagnosis)
  • Helicobacter Infections (blood, diagnosis)
  • Helicobacter pylori
  • Humans
  • Male
  • Middle Aged
  • Pepsinogens (blood)

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