Ifosfamide nephrotoxicity in children: histopathological features in two cases.

Abstract

We report on two children with rhabdomyosarcoma who received ifosfamide as part of their chemotherapy schedule. Both children subsequently developed severe ifosfamide-induced nephrotoxicity, necessitating electrolyte supplementation. We describe the histopathological findings of renal biopsies performed in these children after the onset of renal dysfunction and comment on the possible mechanisms involved in ifosfamide nephrotoxicity.

• Authors: B J Morland, J R Mann, D V Milford, F Raafat, M C Stevens
• Journal: Medical and pediatric oncology (Med Pediatr Oncol) Vol. 27 Issue 1 Pg. 57-61 (Jul 1996) ISSN: 0098-1532 [Print] United States
• PMID: 8614393 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Antineoplastic Agents, Alkylating
• Ifosfamide

Topics

• Adult
• Antineoplastic Agents, Alkylating (adverse effects)
• Biopsy
• Child
• Child, Preschool
• Female
• Humans
• Ifosfamide (adverse effects)
• Kidney Diseases (chemically induced, pathology)
• Male
• Middle Aged
• Rhabdomyosarcoma (drug therapy)