Abstract | BACKGROUND & AIMS: METHODS: RESULTS: In vitro, 22-oxa-calcitriol and calcitriol markedly inhibited the proliferation (3 of 9 cell lines) and caused a G1 phase cell cycle arrest by appearance of numerous domes. In vivo, 22-oxa-calcitriol inhibited the growth of BxPC-3 xenografts more significantly than calcitriol without including hypercalcemia. Hs 766T, showing no response to either agent, had the second highest receptor contents with no abnormalities in its primary structure deduced by receptor complementary DNA. CONCLUSIONS:
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Authors | S Kawa, K Yoshizawa, M Tokoo, H Imai, H Oguchi, K Kiyosawa, T Homma, T Nikaido, K Furihata |
Journal | Gastroenterology
(Gastroenterology)
Vol. 110
Issue 5
Pg. 1605-13
(May 1996)
ISSN: 0016-5085 [Print] United States |
PMID | 8613068
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Receptors, Calcitriol
- Calcitriol
- maxacalcitol
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Topics |
- Animals
- Antineoplastic Agents
(pharmacology)
- Base Sequence
- Calcitriol
(analogs & derivatives, pharmacology)
- Cell Division
(drug effects)
- DNA Mutational Analysis
- Drug Screening Assays, Antitumor
- Female
- Humans
- Mice
- Mice, Nude
- Molecular Sequence Data
- Mutation
- Neoplasm Transplantation
- Pancreatic Neoplasms
(genetics, metabolism, pathology)
- Receptors, Calcitriol
(genetics, metabolism)
- Tumor Cells, Cultured
(drug effects, metabolism, pathology)
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